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Huimin Ran Selected Research

Saposins

1/2019Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype.
4/2011Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
3/2010Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.
2/2010Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse.
8/2008Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.
4/2007Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.

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Huimin Ran Research Topics

Disease

6Gaucher Disease (Gaucher's Disease)
01/2019 - 10/2009
3Cystic Fibrosis (Mucoviscidosis)
12/2004 - 11/2003
3Infections
12/2004 - 11/2003
2Lysosomal Storage Diseases (Lysosomal Storage Disease)
10/2009 - 04/2007
1Wolman Disease (Wolman's Disease)
07/2014
1Metachromatic Leukodystrophy due to Saposin B Deficiency
06/2013
1Tremor (Tremors)
06/2013
1Metachromatic Leukodystrophy (Sulfatide Lipidosis)
08/2008
1Bronchiectasis
07/2006
1Pseudomonas Infections
12/2004
1Necrosis
07/2004

Drug/Important Bio-Agent (IBA)

6SaposinsIBA
01/2019 - 04/2007
3AcidsIBA
01/2019 - 04/2011
3GlucosidasesIBA
01/2019 - 04/2011
3Glucosylceramides (Glucocerebrosides)IBA
04/2011 - 02/2010
3Glucosylceramidase (Glucocerebrosidase)IBA
03/2010 - 10/2009
3Pregnenolone Carbonitrile (PCN)IBA
07/2006 - 07/2004
3PyocyanineIBA
12/2004 - 11/2003
2sphingosyl beta-glucosideIBA
04/2011 - 03/2010
1Sterol Esterase (Hormone-Sensitive Lipase)IBA
07/2014
1Galactosylceramides (Galactocerebrosides)IBA
06/2013
1AT 61IBA
06/2013
1Sulfoglycosphingolipids (Sulfatides)IBA
06/2013
1isofagomineIBA
04/2011
1Diltiazem (Cardizem)FDA LinkGeneric
10/2009
1L-Type Calcium Channels (Dihydropyridine Receptor)IBA
10/2009
1Verapamil (Calan)FDA LinkGeneric
10/2009
1phenazineFDA Link
07/2004
1Adenosine Triphosphatases (ATPase)IBA
11/2003

Therapy/Procedure

1Therapeutics
03/2010